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Anti-FGFR3 Antibody (6S223) (Synonyms: JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CE...)
Catalog No. TMAH-00434 Copy Product Info
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Anti-FGFR3 Antibody (6S223) is an antibody targeting FGFR3. Anti-FGFR3 Antibody (6S223) can be used in ELISA,WB.
Anti-FGFR3 Antibody (6S223)
Copy Product Info🥰Excellent
Catalog No. TMAH-00434
Synonyms JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH
Anti-FGFR3 Antibody (6S223) is an antibody targeting FGFR3. Anti-FGFR3 Antibody (6S223) can be used in ELISA,WB.
Anti-FGFR3 Antibody
(6S223)
(6S223)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-FGFR3 Antibody (6S223) is an antibody targeting FGFR3. Anti-FGFR3 Antibody (6S223) can be used in ELISA,WB. |
| Synonyms | JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH |
| Ig Type | Rabbit IgG |
| Clone | 6S223 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: U87 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate -All lanes: FGFR3 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 88, 89, 76, 86 kDa -Observed band size: 115 kDa |
| Application | |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22-week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isof |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human FGFR3 |
| Antigen Species | Human |
| Gene Name | FGFR3 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Signal transduction, Stem cells |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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