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RBPJ Inhibitor-1

Catalog No. T35566 CAS 2682114-39-0

Synonyms: RIN1

RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation[1].

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RBPJ Inhibitor-1, CAS 2682114-39-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 139.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 723.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.58%

Biological Description

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Description

RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation[1].

In vitro

RBPJ Inhibitor-1 (RIN1) (2 μM) induced changes in gene expression that resembled siRNA silencing of RBPJ rather than inhibition at the level of NOTCH itself. Consistent with the disruption of NOTCH signaling, RIN1 (0.6 μM) inhibited the proliferation of hematologic cancer cell lines and promoted skeletal muscle differentiation from C2C12 myoblasts. Thus, RIN1 inhibits RBPJ in its repressing and activating contexts and can be exploited for chemical biology and therapeutic applications.[1]

Synonyms	RIN1
Molecular Weight	311.31
Formula	C17H14FN3O2
CAS No.	2682114-39-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (722.8 mM), Sonication is recommended.

References and Literature

1. Hurtado C, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019;9(1):10811. 2. Fujioka M, et al. Cloning of a novel splicing variant of RIN1 and its expression in gastric and colon cancer. Oncol Res. 2009;17(11-12):593-599. 3. Milstein M, et al. RIN1 is a breast tumor suppressor gene. Cancer Res. 2007;67(24):11510-11516.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Active Compound Library Inhibitor Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

RBPJ Inhibitor-1 2682114-39-0 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase RIN-1 RIN1 RIN 1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.