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L-Histidine monohydrocholoride

Name: L-Histidine monohydrocholoride
Brand: TargetMol
SKU: TN8219
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN8219 Copy Product Info

Purity: 99.88%

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L-Histidine monohydrocholoride is the essential amino acid. It is highly water-soluble and is commonly used in cell culture media, buffer systems, and biochemical research. Its imidazole side chain can participate in metal ion binding and acid-base buffering, playing a crucial role in protein structural stability and enzymatic catalysis.

Cas No. 645-35-2

Pack Size	Price	USA Stock	Global Stock	Quantity
5 g	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	L-Histidine monohydrocholoride is the essential amino acid. It is highly water-soluble and is commonly used in cell culture media, buffer systems, and biochemical research. Its imidazole side chain can participate in metal ion binding and acid-base buffering, playing a crucial role in protein structural stability and enzymatic catalysis.
In vitro	L-Histidine monohydrocholoride significantly reduced air-liquid biofilm formation and adhesion to polystyrene in Flor yeast, but did not affect the transcriptional levels of the FLO11 gene. L-Histidine monohydrocholoride completely inhibited growth, and its effect on survival was inversely proportional to FLO11 expression. L-Histidine monohydrocholoride did not affect the survival of the Δflo11 and S288c strains. L-Histidine monohydrocholoride also altered the content of chitin and polysaccharides in the cell walls of Flor yeast.
In vivo	L-Histidine monohydrocholoride (100 mg/kg) completely inhibited cerebral edema in rats treated with thioacetamide. In the L-Histidine monohydrocholoride diet group, histamine release in hypothalamic tissue induced by high potassium ions was only 60% of that in the control group; no significant changes were observed in the concentrations of other monoamines and their metabolites. The open field test indicated that the L-Histidine monohydrocholoride-fed group spent less time in the central area. In the light/dark box test, the L-Histidine monohydrocholoride-fed group also spent less time in the light compartment, suggesting that the L-Histidine monohydrocholoride diet may induce anxiety-like behavior.

Chemical Properties

Molecular Weight	191.62
Formula	C₆H₁₀ClN₃O₂
Cas No.	645-35-2
Smiles	C([C@@H](C(O)=O)N)C1=CN=CN1.Cl
Sequence	H-His-OH
Sequence Short	H

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (208.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2187 mL	26.0933 mL	52.1866 mL	260.9331 mL
5 mM	1.0437 mL	5.2187 mL	10.4373 mL	52.1866 mL
10 mM	0.5219 mL	2.6093 mL	5.2187 mL	26.0933 mL
20 mM	0.2609 mL	1.3047 mL	2.6093 mL	13.0467 mL
50 mM	0.1044 mL	0.5219 mL	1.0437 mL	5.2187 mL
100 mM	0.0522 mL	0.2609 mL	0.5219 mL	2.6093 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: L-Histidine monohydrocholoride chemical structure | L-Histidine monohydrocholoride in vivo | L-Histidine monohydrocholoride in vitro | L-Histidine monohydrocholoride formula | L-Histidine monohydrocholoride molecular weight