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SLP9101555

🥰Excellent
Catalog No. T63047

SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extracellular S1P sphingosine 1-phosphate (S1P) levels.

SLP9101555

SLP9101555

🥰Excellent
Purity: 99.45%
Catalog No. T63047
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extracellular S1P sphingosine 1-phosphate (S1P) levels.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$350In StockIn Stock
5 mg$828In StockIn Stock
10 mg$1,130In StockIn Stock
25 mg$1,590In StockIn Stock
50 mg$1,980In StockIn Stock
100 mg$2,500In StockIn Stock
500 mg$4,900-In Stock
1 mL x 10 mM (in DMSO)$698In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.45%
ee:100%
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COA CSFC FNMR HNMR IC LCMS

Product Introduction

Bioactivity
Description
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extracellular S1P sphingosine 1-phosphate (S1P) levels.
Targets&IC50
SPHK1:18000 ± 220 nM(Ki), SPHK2:90 ± 11 nM(Ki)
In vivo
SLP9101555 (compound 14c) (5 mg/kg; I.P.; single administration) significantly elevates blood S1P levels.[1]
Chemical Properties
Molecular Weight471.95
FormulaC22H29ClF3N5O
SmilesFC(F)(F)C1=CC(C2=NOC([C@@H]3CCCN3C(N)=N)=N2)=CC=C1CCC4CCCCC4.Cl
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.72 mg/mL (10.00 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1189 mL10.5943 mL21.1887 mL105.9434 mL
5 mM0.4238 mL2.1189 mL4.2377 mL21.1887 mL
10 mM0.2119 mL1.0594 mL2.1189 mL10.5943 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SphK2S1PReceptorS1PR1S1P ReceptorLPLReceptorLPL Receptor
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