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GlyH-101

Name: GlyH-101
Brand: TargetMol
SKU: T2451
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2451Cas No. 328541-79-3

Alias GlyH 101

GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

GlyH-101

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Purity: 98.78%

Catalog No. T2451Alias GlyH 101Cas No. 328541-79-3

GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$110	In Stock	In Stock
25 mg	$233	In Stock	In Stock
50 mg	$393	In Stock	In Stock
100 mg	$589	In Stock	In Stock
200 mg	$839	-	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.78%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
Targets&IC50	CFTR:4.3 μM(Ki)
In vitro	GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3]
In vivo	In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1]
Synonyms	GlyH 101

Chemical Properties

Molecular Weight	493.15
Formula	C₁₉H₁₅Br₂N₃O₃
Cas No.	328541-79-3
Smiles	OC1=C(Br)C(=O)\C(=C\NNC(=O)CNc2ccc3ccccc3c2)C=C1Br
Relative Density.	1.73 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49.3 mg/mL (99.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0278 mL	10.1389 mL	20.2778 mL	101.3890 mL
5 mM	0.4056 mL	2.0278 mL	4.0556 mL	20.2778 mL
10 mM	0.2028 mL	1.0139 mL	2.0278 mL	10.1389 mL
20 mM	0.1014 mL	0.5069 mL	1.0139 mL	5.0695 mL
50 mM	0.0406 mL	0.2028 mL	0.4056 mL	2.0278 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc