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Anti-AKR1B10 Polyclonal Antibody

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Catalog No. TMAB-02406

Anti-AKR1B10 Polyclonal Antibody is a Rabbit antibody targeting AKR1B10. Anti-AKR1B10 Polyclonal Antibody can be used in WB.

Anti-AKR1B10 Polyclonal Antibody

Anti-AKR1B10 Polyclonal Antibody

😃Good
Catalog No. TMAB-02406
Anti-AKR1B10 Polyclonal Antibody is a Rabbit antibody targeting AKR1B10. Anti-AKR1B10 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2237-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-AKR1B10 Polyclonal Antibody is a Rabbit antibody targeting AKR1B10. Anti-AKR1B10 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Rabbit)
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationLysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway.
Tissue SpecificityFound in many tissues. Highly expressed in small intestine, colon and adrenal gland.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundAKR1B10 is also known as aldose reductase-like-1 (ARL-1), small intestine reductase (SI reductase) or aldose reductase-related protein (ARP or hARP). AKR1B10 is found in many tissues but is predominantly expressed in small intestine, colon and adrenal gland. AKR1B10 is an efficient reductase for aliphatic and aromatic aldehydes. It plays a role in steroid metabolism as well as detoxification of aldehydes in digested food, and may be involved in the retinal-retinoic acid signaling pathway. AKR1B10 is prominently overexpressed in non-small cell lung carcinoma and adenocarcinoma. Cigarette smoking is an independent variable responsible for this overexpression. AKR1B10 may play a role regulating cell proliferation and cellular response to carbonyl stress.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human AKR1B10
Antigen Species
Human
Gene Name
AKR1B10
Gene ID
57016
Protein Name
Aldo-keto reductase family 1 member B10
Uniprot ID
O60218
Function
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
Chemical Properties
Molecular WeightTheoretical: 35 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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