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L-745870

Name: L-745870
Brand: TargetMol
SKU: T11799L
Rating: 4.5 (1 reviews)

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Catalog No. T11799LCas No. 158985-00-3

L-745870 is an orally active, selective, and efficient dopamine D4 receptor antagonist that crosses the blood-brain barrier. It also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors, useful in neurological disease studies.

L-745870

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Catalog No. T11799LCas No. 158985-00-3

Pack Size	Price	Availability
2 mg	$35	5 days
5 mg	$59	1-2 weeks
10 mg	$98	1-2 weeks
25 mg	$198	1-2 weeks
50 mg	$329	1-2 weeks
100 mg	$478	1-2 weeks
1 mL x 10 mM (in DMSO)	$63	In Stock

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Product Introduction

Bioactivity

Description	L-745870 is an orally active, selective, and efficient dopamine D4 receptor antagonist that crosses the blood-brain barrier. It also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors, useful in neurological disease studies.
Targets&IC50	D4 receptor (human):0.43 nM (Ki), D2 receptor (human):960 nM (Ki), D3 receptor (human):2300 nM (Ki)
In vitro	L-745870 binds specifically to the human dopamine D4 receptor with a binding affinity (Ki) of 0.43 nM. L-745870 (0.1-1 μM) exhibits D4 receptor antagonist activity, reversing dopamine (1 μM) -mediated adenylate cyclase inhibition in hD4HEK and hD4CHO cells. [1]
In vivo	L-745870 (0, 1, or 2 μg/5 μl,icv injection) acts on dopamine D4 receptors to reduce sucrose consumption in a dose-dependent manner in hedonic-fed rat models. [2] L-745870 (5 and 10 mg/kg, systemic injection) inhibited PFC slow rhythm (delta, 2-4 Hz) and enhanced HPCθ in rats. [3]

Chemical Properties

Molecular Weight	326.82
Formula	C₁₈H₁₉ClN₄
Cas No.	158985-00-3
Smiles	ClC1=CC=C(C=C1)N2CCN(CC3=CNC=4N=CC=CC43)CC2
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (48.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0598 mL	15.2989 mL	30.5979 mL	152.9894 mL
5 mM	0.6120 mL	3.0598 mL	6.1196 mL	30.5979 mL
10 mM	0.3060 mL	1.5299 mL	3.0598 mL	15.2989 mL
20 mM	0.1530 mL	0.7649 mL	1.5299 mL	7.6495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc