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L-745870

Name: L-745870
Brand: TargetMol
SKU: T11799L
Rating: 4.5 (1 reviews)

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Catalog No. T11799LCas No. 158985-00-3

L-745870 is an orally active, selective, and efficient dopamine D4 receptor antagonist that crosses the blood-brain barrier. It also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors, useful in neurological disease studies.

L-745870

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Catalog No. T11799LCas No. 158985-00-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	5 days	5 days
5 mg	$59	1-2 weeks	1-2 weeks
10 mg	$98	1-2 weeks	1-2 weeks
25 mg	$198	1-2 weeks	1-2 weeks
50 mg	$329	1-2 weeks	1-2 weeks
100 mg	$478	1-2 weeks	1-2 weeks
1 mL x 10 mM (in DMSO)	$63	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	L-745870 is an orally active, selective, and efficient dopamine D4 receptor antagonist that crosses the blood-brain barrier. It also inhibits D2 receptors, 5-HT2 receptors, and α-adrenergic receptors, useful in neurological disease studies.
Targets&IC50	D3 receptor (human):2300 nM (Ki), D2 receptor (human):960 nM (Ki), D4 receptor (human):0.43 nM (Ki)
In vitro	L-745870 binds specifically to the human dopamine D4 receptor with a binding affinity (Ki) of 0.43 nM. L-745870 (0.1-1 μM) exhibits D4 receptor antagonist activity, reversing dopamine (1 μM) -mediated adenylate cyclase inhibition in hD4HEK and hD4CHO cells. [1]
In vivo	L-745870 (0, 1, or 2 μg/5 μl,icv injection) acts on dopamine D4 receptors to reduce sucrose consumption in a dose-dependent manner in hedonic-fed rat models. [2] L-745870 (5 and 10 mg/kg, systemic injection) inhibited PFC slow rhythm (delta, 2-4 Hz) and enhanced HPCθ in rats. [3]

Chemical Properties

Molecular Weight	326.82
Formula	C₁₈H₁₉ClN₄
Cas No.	158985-00-3
Smiles	ClC1=CC=C(C=C1)N2CCN(CC3=CNC=4N=CC=CC43)CC2
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (48.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0598 mL	15.2989 mL	30.5979 mL	152.9894 mL
5 mM	0.6120 mL	3.0598 mL	6.1196 mL	30.5979 mL
10 mM	0.3060 mL	1.5299 mL	3.0598 mL	15.2989 mL
20 mM	0.1530 mL	0.7649 mL	1.5299 mL	7.6495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc