ITPRIPL1 Protein, Human, Recombinant (hFc)

Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.

ITPRIPL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q6GPH6-1.

Human

HEK293 Cells

> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC

Inositol 1,4,5-trisphosphate Receptor Interacting Protein-Like 1 or ITPRIPL1 is a transmembrane protein with broad expression in the testis associated with immune evasion. In fact, ITPRIPL1 is a molecule specifically expressed in immune privileged tissues, “hot” tumors without PD-L1 expression, and non-responding tumors to PD-1 blockade therapy. ITPRIPL1 has been shown to impair T cell function in vitro and in vivo through CD3e with experimental evidence supporting a negative correlation between ITPRIPL1 expression level in antigen-presenting cells and T cell cytotoxicity. ITPRIPL1 was a hypermethylated-low expression gene in breast cancer and acted as an independent biomarker for the prognosis of lung adenocarcinoma by using bioinformatics methods. Thus, targeting the ITPRIPL1-CD3e axis, especially in PD-1 - PD-L1 negative patients, is a promising therapeutic strategy to reduce immune evasion.