YNT-185 dihydrochloride

Name: YNT-185 dihydrochloride
Brand: TargetMol
SKU: T37112
Rating: 4.5 (1 reviews)

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Catalog No. T37112Cas No. 1804978-82-2

Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

YNT-185 dihydrochloride

😃Good

Catalog No. T37112Cas No. 1804978-82-2

Pack Size	Price	Availability	Quantity
2 mg	$113	5 days

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Product Introduction

Bioactivity

Description	Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
Targets&IC50	OX2 receptor:0.028 μM (EC50), OX1 receptor:2.75 μM (EC50)

Chemical Properties

Molecular Weight	688.67
Formula	C₃₃H₃₉Cl₂N₅O₅S
Cas No.	1804978-82-2

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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