Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 113.00 |
Description | Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice. |
Targets&IC50 | OX1 receptor:2.75 μM (EC50), OX2 receptor:0.028 μM (EC50) |
Molecular Weight | 688.67 |
Formula | C33H39Cl2N5O5S |
CAS No. | 1804978-82-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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YNT-185 dihydrochloride 1804978-82-2 YNT-185 YNT 185 YNT185 dihydrochloride YNT-185 Dihydrochloride YNT 185 dihydrochloride YNT185 YNT 185 Dihydrochloride YNT185 Dihydrochloride inhibitor inhibit