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GOT1 inhibitor-1

Name: GOT1 inhibitor-1
Brand: TargetMol
SKU: T8766
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8766Cas No. 732973-87-4

Alias GOT1 inhibitor 2c

GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.

GOT1 inhibitor-1

🥰Excellent

Purity: 99.70%

Catalog No. T8766Alias GOT1 inhibitor 2cCas No. 732973-87-4

GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$558	In Stock	In Stock
50 mg	$788	In Stock	In Stock
100 mg	$1,120	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.70%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.
Targets&IC50	GOT1:8.2 μM
In vitro	In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 of 8.2 μM[1].
Synonyms	GOT1 inhibitor 2c

Chemical Properties

Molecular Weight	354.83
Formula	C₁₉H₁₉ClN₄O
Cas No.	732973-87-4
Smiles	Clc1ccc(NC(=O)N2CCN(CC2)c2cccc3[nH]ccc23)cc1
Relative Density.	1.387 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (338.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8183 mL	14.0913 mL	28.1825 mL	140.9125 mL
5 mM	0.5637 mL	2.8183 mL	5.6365 mL	28.1825 mL
10 mM	0.2818 mL	1.4091 mL	2.8183 mL	14.0913 mL
20 mM	0.1409 mL	0.7046 mL	1.4091 mL	7.0456 mL
50 mM	0.0564 mL	0.2818 mL	0.5637 mL	2.8183 mL
100 mM	0.0282 mL	0.1409 mL	0.2818 mL	1.4091 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc