COX-2-IN-57

Name: COX-2-IN-57
Brand: TargetMol
SKU: T213244
Rating: 4.5 (1 reviews)

Catalog No. T213244 Copy Product Info

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COX-2-IN-57 is an orally active COX-2 inhibitor with an IC50 value of 0.02 μM. In a rat model with neuropathy induced by Cisplatin/radiation, it reduces MyD88 expression and lowers serum levels of COX-2, PGE2, and COX-1. COX-2-IN-57 demonstrates excellent analgesic effects in hot plate, cold allodynia, and Randall-Selitto tests, and provides liver/kidney protection. It is applicable for inflammation research.

COX-2-IN-57

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Catalog No. T213244

COX-2-IN-57

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	COX-2-IN-57 is an orally active COX-2 inhibitor with an IC50 value of 0.02 μM. In a rat model with neuropathy induced by Cisplatin/radiation, it reduces MyD88 expression and lowers serum levels of COX-2, PGE2, and COX-1. COX-2-IN-57 demonstrates excellent analgesic effects in hot plate, cold allodynia, and Randall-Selitto tests, and provides liver/kidney protection. It is applicable for inflammation research.
Targets&IC50	COX-2:0.02 μM
In vivo	COX-2-IN-57 (Compound 16), administered orally at 20 mg/kg as a single dose, exhibits dual anti-inflammatory and analgesic effects in a carrageenan-induced paw edema and hyperalgesia model in female Wistar rats. Additionally, COX-2-IN-57, given orally at the same dosage for 5 consecutive days, significantly inhibits inflammation in a rat model induced by Cisplatin/γ-ray.

Chemical Properties

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Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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