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UGT8-IN-1

Name: UGT8-IN-1
Brand: TargetMol
SKU: T40046
Price: 126 USD
Availability: InStock
Rating: 5 (10 reviews)

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Synonyms:

Catalog No. T40046 Copy Product Info

Purity: 99.60%

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UGT8-IN-1 is an orally active, blood-brain barrier-penetrating small-molecule inhibitor that targets UGT8 (ceramide galactosyltransferase). By inhibiting pathways involved in sphingolipid synthesis, it is used in research into the mechanisms of neurological disorders such as lysosomal storage diseases.

Cas No. 2414349-93-0

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Pack Size	Price	USA Stock	Global Stock
1 mg	$126	-	In Stock
5 mg	$310	-	In Stock
10 mg	$412	-	In Stock
25 mg	$601	-	In Stock
50 mg	$901	-	In Stock
1 mL x 10 mM (in DMSO)	$366	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.60%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vivo

UGT8-IN-1 (compound 19) exhibits the T1/2 of 4.3 h, 1.13 h and 13.6 h by iv (1 mg/kg) administration in rat, mouse and dog, respectively.
UGT8-IN-1 (compound 19) shows F% of 40%, 34% and 52% by oral (3 mg/kg) administration in rat, mouse and dog, respectively.
UGT8-IN-1 (compound 19, orally twice a day for three days) shows ≥90% inhibition of incorporation of 13 C-Gal into GalCer and SFT, at all three doses tested, with the estimated ED 50 s of <3 mg/kg for inhibition of both SFT and GalCer.
UGT8-IN-1 (compound 19) has very high plasma protein and tissue binding (>99%)[1].

Chemical Properties

Molecular Weight	528.47
Formula	C₂₀H₂₂F₆N₄O₄S
Cas No.	2414349-93-0
Smiles	C(NC)(=O)C=1C=2C(=C(C(F)(F)F)C=C(N2)N3CCC(OC(N[C@H](COC(F)(F)F)C)=O)CC3)SC1

Storage & Solubility Information

Storage

Keep away from moistureStore under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 92 mg/mL (174.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8923 mL	9.4613 mL	18.9226 mL	94.6128 mL
5 mM	0.3785 mL	1.8923 mL	3.7845 mL	18.9226 mL
10 mM	0.1892 mL	0.9461 mL	1.8923 mL	9.4613 mL
20 mM	0.0946 mL	0.4731 mL	0.9461 mL	4.7306 mL
50 mM	0.0378 mL	0.1892 mL	0.3785 mL	1.8923 mL
100 mM	0.0189 mL	0.0946 mL	0.1892 mL	0.9461 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.