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2-Thiouracil

Name: 2-Thiouracil
Brand: TargetMol
SKU: T1310
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1310Cas No. 141-90-2

Alias Thiouracil, Deracil

2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.

2-Thiouracil

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Purity: 99.89%

Catalog No. T1310Alias Thiouracil, DeracilCas No. 141-90-2

2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.

Pack Size	Price	Availability	Quantity
1 g	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.89%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
Targets&IC50	nNOS:20 μM (Ki)
In vivo	2-Thiouracil is a selective neuronal nitric oxide synthase inhibitor capable of antagonizing tetrahydrobiopterin-dependent enzymatic activation.
Synonyms	Thiouracil, Deracil

Chemical Properties

Molecular Weight	128.15
Formula	C₄H₄N₂OS
Cas No.	141-90-2
Smiles	SC1=NC=CC(=O)N1
Relative Density.	1.46g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (429.18 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.8034 mL	39.0168 mL	78.0336 mL	390.1678 mL
5 mM	1.5607 mL	7.8034 mL	15.6067 mL	78.0336 mL
10 mM	0.7803 mL	3.9017 mL	7.8034 mL	39.0168 mL
20 mM	0.3902 mL	1.9508 mL	3.9017 mL	19.5084 mL
50 mM	0.1561 mL	0.7803 mL	1.5607 mL	7.8034 mL
100 mM	0.0780 mL	0.3902 mL	0.7803 mL	3.9017 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc