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PDE9-IN-1

🥰Excellent
Catalog No. T12395Cas No. 2305087-92-5

PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).

PDE9-IN-1

PDE9-IN-1

🥰Excellent
Purity: 99.86%
Catalog No. T12395Cas No. 2305087-92-5
PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$36In StockIn Stock
5 mg$86In StockIn Stock
10 mg$139In StockIn Stock
25 mg$247In StockIn Stock
50 mg$361In StockIn Stock
100 mg$523In StockIn Stock
200 mg$739-In Stock
1 mL x 10 mM (in DMSO)$95In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.86%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).
Targets&IC50
PDE9A:8.7 nM
In vivo
In the Unilateral common carotid artery occlusion (UCCAO) mouse model, PDE9-IN-1 (2.5-5.0 mg/kg; orally) significantly reduces the day 6 escape latency time, increases the frequency of platform area crossings, and recoveres learning and memory function. High dose group possibly improved the escape latency time of mice[1].
Chemical Properties
Molecular Weight362.4
FormulaC17H23FN6O2
Cas No.2305087-92-5
SmilesO=C1C2=C(N(N=C2)C3CCCC3)NC(N[C@@H](C(=O)N4CC[C@H](F)C4)C)=N1
Relative Density.1.58 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (124.17 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7594 mL13.7969 mL27.5938 mL137.9691 mL
5 mM0.5519 mL2.7594 mL5.5188 mL27.5938 mL
10 mM0.2759 mL1.3797 mL2.7594 mL13.7969 mL
20 mM0.1380 mL0.6898 mL1.3797 mL6.8985 mL
50 mM0.0552 mL0.2759 mL0.5519 mL2.7594 mL
100 mM0.0276 mL0.1380 mL0.2759 mL1.3797 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PDE9-IN-1PDE-9-IN-1PDE9IN1PDE9 IN 1PDE9
Related Tags: buy PDE9-IN-1 | purchase PDE9-IN-1 | PDE9-IN-1 cost | order PDE9-IN-1 | PDE9-IN-1 chemical structure | PDE9-IN-1 in vivo | PDE9-IN-1 formula | PDE9-IN-1 molecular weight
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