This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
3-IN-PP1
Catalog No. T60718 CAS
2227110-54-3
3-IN-PP1, a potent protein kinase D (PKD) inhibitor, exhibits pan-PKD inhibitory activity with IC50 values of 108 nM for PKD1, 94 nM for PKD2, and 108 nM for PKD3. Additionally, it serves as a broad-spectrum anticancer agent by inhibiting the growth of various tumor cells. 3-IN-PP1 is utilized in cancer research [1].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
3-IN-PP1, a potent protein kinase D (PKD) inhibitor, exhibits pan-PKD inhibitory activity with IC50 values of 108 nM for PKD1, 94 nM for PKD2, and 108 nM for PKD3. Additionally, it serves as a broad-spectrum anticancer agent by inhibiting the growth of various tumor cells. 3-IN-PP1 is utilized in cancer research [1].
In vitro
3-IN-PP1 is a potent inhibitor of the protein kinase D (PKD) family, including PKD1, PKD2, and PKD3, demonstrating IC50 values of 108, 94, and 108 nM, respectively [1]. At a concentration of 5 µM over a period of 0-114 hours, it exhibits strong anti-proliferative effects on PANC-1 cells, significantly inhibiting their proliferation after 96 and 144 hours of treatment [1]. Furthermore, with a concentration of 20 µM applied for 1 hour, 3-IN-PP1 effectively impedes PKD-dependent phosphorylation of cortactin in PANC-1 cells, indicating its role in disrupting cellular processes crucial for cancer cell growth and metastasis [1]. Additionally, this compound has been found to inhibit the growth of various tumor cells, with IC50 values ranging from 1.6 to 39.2 µM [1]. These findings highlight 3-IN-PP1's potential as an effective agent in cancer research and therapy, particularly for treatments targeting the PKD pathway and related mechanisms in tumor cells.
Molecular Weight
306.36
Formula
C17H18N6
CAS No.
2227110-54-3
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.