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RBN-3143

Catalog No. T67844 CAS 2360853-16-1

RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines. RBN-3143 exhibits research potential of lung inflammation.

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RBN-3143, CAS 2360853-16-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 87.00
5 mg	In stock	$ 213.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 533.00
50 mg	In stock	$ 768.00
100 mg	In stock	$ 1,080.00
500 mg	In stock	$ 2,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 235.00

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Purity: 98.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines. RBN-3143 exhibits research potential of lung inflammation.
Targets&IC50	PARP14:4 nM
In vivo	RBN-3143 (5 μg; Intranasal administration) can improve the steroid resistant asthma mouse model [1].

Molecular Weight	449.54
Formula	C22H28FN3O4S
CAS No.	2360853-16-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11.2 mg/mL (25.0 mM), Sonication and heating to 80℃ are recommended.

References and Literature

1. Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal 2022 60: 4642.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library DNA Damage & Repair Compound Library Clinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RBN-3143 2360853-16-1 Chromatin/Epigenetic DNA Damage/DNA Repair PARP RBN 3143 RBN3143 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.