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Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565)
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Catalog No. TMAY-01654
Alias VSCN1, p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, FERLK, erbB3-S, ErbB-3, Erb-B3, ErbB3, c-erbB-3, c-erbB3
Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) is a Rabbit antibody targeting Phospho-HER3/ErbB3 (Tyr1289). Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) can be used in WB.
Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565)
Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565)
😃Good
Catalog No. TMAY-01654Alias VSCN1, p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, FERLK, erbB3-S, ErbB-3, Erb-B3, ErbB3, c-erbB-3, c-erbB3
Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) is a Rabbit antibody targeting Phospho-HER3/ErbB3 (Tyr1289). Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $82 | 7-10 days | |
| 100 μL | $233 | 7-10 days |
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Chemical Properties
| Description | Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) is a Rabbit antibody targeting Phospho-HER3/ErbB3 (Tyr1289). Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) can be used in WB. |
| Alias | VSCN1, p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, FERLK, erbB3-S, ErbB-3, Erb-B3, ErbB3, c-erbB-3, c-erbB3 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5D565 |
| Reactivity | Human;
Species predicted to react based on 100% sequence homology: cynomolgus |
| Verified Activity | 1. Western blot analysis of extracts from serum-starved MCF-7, untreated (-) or treated with neuregulin-1 (100 ng/mL, 5 min) using Phospho-HER3/ErbB3 (Tyr1289) rabbit monoclonal Antibody at 1:2000 dilution (upper), or Anti-HER3/ERBB3 Antibody, Rabbit Polyclonal at 1:2000 dilution (middle), or Beta-Tubulin Loading Control Antibody, Mouse MAb at 1:2000 dilution (lower) 2. Western blot analysis of extracts from serum-starved MCF-7, untreated (line A); treated with neuregulin-1(100ng/ml, 5min; +) (line B); treated with neuregulin-1 and λ-phosphatase (line C) using Phospho-HER3/ErbB3 (Tyr1289) rabbit monoclonal Antibody at 1:100000 dilution. (Validation Experiment) |
| Application | WB |
| Recommended Dose | WB: 1:2000-1:20000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Tyr1289 of the Human Phospho-HER3/ErbB3. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Research Background | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | A synthetic phosphopeptide corresponding to residues around Tyr1289 of the Human Phospho-HER3/ErbB3 |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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