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Urabrelimab
🥰Excellent
Catalog No. T76965Cas No. 2249722-58-3
Alias SRF-231, SRF231
Urabrelimab (SRF-231) is a humanized antibody targeting CD47, with antitumor activity. It blocks the CD47-SIRPα interaction and is used in studies of advanced malignant solid tumors.
Urabrelimab
Urabrelimab
🥰Excellent
Catalog No. T76965Alias SRF-231, SRF231Cas No. 2249722-58-3
Urabrelimab (SRF-231) is a humanized antibody targeting CD47, with antitumor activity. It blocks the CD47-SIRPα interaction and is used in studies of advanced malignant solid tumors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | In Stock | In Stock | |
| 5 mg | $579 | In Stock | In Stock | |
| 10 mg | $928 | - | In Stock | |
| 25 mg | $1,370 | - | In Stock | |
| 50 mg | $1,850 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Urabrelimab (SRF-231) is a humanized antibody targeting CD47, with antitumor activity. It blocks the CD47-SIRPα interaction and is used in studies of advanced malignant solid tumors. |
| In vitro | Urabrelimab specifically binds to human CD47 to induce phagocytosis in malignant B-cell lymphoma. Urabrelimab (10 μg/mL) induced tumor cell death in a CD32A-dependent manner. [1] |
| In vivo | Urabrelimab（100 μg, 3 times/week for 3 weeks) showed antitumor activity in a range of blood tumor xenotransplantation models. [1] |
| Synonyms | SRF-231, SRF231 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID |
| Cas No. | 2249722-58-3 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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