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Methotrexate Diglutamate

Name: Methotrexate Diglutamate
Brand: TargetMol
SKU: T25886
Price: 978 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T25886Cas No. 41600-13-9

Alias NSC-269401, NSC269401, NSC 269401

Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.

Methotrexate Diglutamate

🥰Excellent

Purity: 98.51%

Catalog No. T25886Alias NSC-269401, NSC269401, NSC 269401Cas No. 41600-13-9

Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.

Pack Size	Price	Availability
1 mg	$978	In Stock
5 mg	$1,960	In Stock
10 mg	$2,650	In Stock
25 mg	$3,930	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.51%

ee:97.90%

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.
Synonyms	NSC-269401, NSC269401, NSC 269401

Chemical Properties

Molecular Weight	583.55
Formula	C₂₅H₂₉N₉O₈
Cas No.	41600-13-9
Smiles	NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
Relative Density.	1.539 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (171.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7136 mL	8.5682 mL	17.1365 mL	85.6825 mL
5 mM	0.3427 mL	1.7136 mL	3.4273 mL	17.1365 mL
10 mM	0.1714 mL	0.8568 mL	1.7136 mL	8.5682 mL
20 mM	0.0857 mL	0.4284 mL	0.8568 mL	4.2841 mL
50 mM	0.0343 mL	0.1714 mL	0.3427 mL	1.7136 mL
100 mM	0.0171 mL	0.0857 mL	0.1714 mL	0.8568 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc