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YAP/TAZ inhibitor-2

Name: YAP/TAZ inhibitor-2
Brand: TargetMol
SKU: T60218
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60218Cas No. 2762617-31-0

YAP/TAZ inhibitor-2 is a potent, orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM, demonstrating anti-proliferative and antitumor activity [1].

YAP/TAZ inhibitor-2

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Purity: 98.65%

Catalog No. T60218Cas No. 2762617-31-0

YAP/TAZ inhibitor-2 is a potent, orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM, demonstrating anti-proliferative and antitumor activity [1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
2 mg	$122	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$528	In Stock	In Stock
50 mg	$763	In Stock	In Stock
100 mg	$1,070	-	In Stock
500 mg	$2,130	-	In Stock
1 mL x 10 mM (in DMSO)	$218	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.65%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	YAP/TAZ inhibitor-2 is a potent, orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM, demonstrating anti-proliferative and antitumor activity [1].
In vitro	YAP/TAZ inhibitor-2 (compound 5) exhibits antiproliferative activity in NCI-H226 cells, with an IC50 value of 5.33 nM over 24 hours at concentrations ranging from 0 to 20000 nM [1].
In vivo	YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) exhibits anti-tumor activity without significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model) [1].

Chemical Properties

Molecular Weight	390.33
Formula	C₁₉H₁₄F₄N₄O
Cas No.	2762617-31-0
Smiles	FC(=C)C(=O)N1CC(C1)n1nc(-c2ccc(cc2)C(F)(F)F)c2cccnc12
Relative Density.	1.45 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (230.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5619 mL	12.8097 mL	25.6193 mL	128.0967 mL
5 mM	0.5124 mL	2.5619 mL	5.1239 mL	25.6193 mL
10 mM	0.2562 mL	1.2810 mL	2.5619 mL	12.8097 mL
20 mM	0.1281 mL	0.6405 mL	1.2810 mL	6.4048 mL
50 mM	0.0512 mL	0.2562 mL	0.5124 mL	2.5619 mL
100 mM	0.0256 mL	0.1281 mL	0.2562 mL	1.2810 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc