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Ac2-26 ammonium
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Catalog No. T78371
Alias Ac2-26 ammonium (151988-33-9 free base)
Ac2-26 ammonium is an Annexin-A1 (AnxA1) N-terminal derived peptide with anti-inflammatory activity and alleviates liver ischemia-reperfusion injury in mice by regulating IL-22/IL-22R1/STAT3 signaling and eNOS pathways.
Ac2-26 ammonium
Ac2-26 ammonium
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Purity: 95.58%
Catalog No. T78371Alias Ac2-26 ammonium (151988-33-9 free base)
Ac2-26 ammonium is an Annexin-A1 (AnxA1) N-terminal derived peptide with anti-inflammatory activity and alleviates liver ischemia-reperfusion injury in mice by regulating IL-22/IL-22R1/STAT3 signaling and eNOS pathways.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | In Stock | In Stock | |
| 5 mg | $123 | In Stock | In Stock | |
| 10 mg | $197 | In Stock | In Stock | |
| 25 mg | $328 | In Stock | In Stock | |
| 50 mg | $538 | In Stock | In Stock | |
| 100 mg | $766 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.58%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ac2-26 ammonium is an Annexin-A1 (AnxA1) N-terminal derived peptide with anti-inflammatory activity and alleviates liver ischemia-reperfusion injury in mice by regulating IL-22/IL-22R1/STAT3 signaling and eNOS pathways. |
| Targets&IC50 | FPR1 (human):1.4 μM (EC50), FPR2 (human):1.8 μM (EC50) |
| In vitro | In radioligand binding assays, Ac2-26 ammonium was able to bind to HEK293 cells expressing human formyl peptide receptor 1 (FPR1) or FPR2, FPR1 (EC50=1.4 μM) and FPR2 (EC50=1.8 μM). Ac2-26 ammonium inhibited lipopolysaccharide (LPS)-induced prostaglandin (E2) and nitric oxide (NO) production in rat microglia. [1] |
| In vivo | In a rat model of ventilator-induced ischemia-reperfusion injury, Ac2-26 ammonium was able to reduce pulmonary edema when administered at a dose of 0.5-1 mg/kg. [2] |
| Synonyms | Ac2-26 ammonium (151988-33-9 free base) |
| Molecular Weight | 3089.43 (free base) |
| Formula | C141H210N32O44S.xNH3 |
| Sequence | Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys |
| Sequence Short | AMVSEFLKQAWFIENEEQEYVQTVK |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 30 mg/mL, when pH is adjusted to 8. Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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