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Desipramine hydrochloride

🥰Excellent
Catalog No. T0991Cas No. 58-28-6
Alias NSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, Desmethylimipramine

Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.

Desipramine hydrochloride
Other Forms of Desipramine hydrochloride:

Desipramine hydrochloride

🥰Excellent
Purity: 99.94%
Catalog No. T0991Alias NSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, DesmethylimipramineCas No. 58-28-6
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$35In StockIn Stock
100 mg$48In StockIn Stock
200 mg$61In Stock-
1 mL x 10 mM (in DMSO)$30In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
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Product Introduction

Bioactivity
Description
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.
Targets&IC50
DAT:78720 nM (Ki), SERT:61 nM (Ki), NET:4 nM (Ki)
SynonymsNSC-114901, Norimipramine, JB-8181, G-35020, EX-4355, Desmethylimipramine
Chemical Properties
Molecular Weight302.842
FormulaC18H23ClN2
Cas No.58-28-6
SmilesCl.CNCCCN1c2ccccc2CCc2ccccc12
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 252 mg/mL (832.12 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (10.9 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3021 mL16.5103 mL33.0205 mL165.1026 mL
5 mM0.6604 mL3.3021 mL6.6041 mL33.0205 mL
10 mM0.3302 mL1.6510 mL3.3021 mL16.5103 mL
20 mM0.1651 mL0.8255 mL1.6510 mL8.2551 mL
50 mM0.0660 mL0.3302 mL0.6604 mL3.3021 mL
100 mM0.0330 mL0.1651 mL0.3302 mL1.6510 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

SLC6A4SLC6A3SERTSerotoninTransporterSerotonin TransporterNSC114901NSC 114901JB8181JB 8181InhibitorinhibitG35020G 35020EX4355EX 4355DopamineReceptorDopamine TransporterDopamine ReceptorDesipramine hydrochlorideDesipramine HydrochlorideDesipramineDATAdrenergicReceptorAdrenergic Receptor5-HTT5HTReceptor5HT Receptor5-HT
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