TNF alpha Protein, Canine, Recombinant

Name: TNF alpha Protein, Canine, Recombinant
Brand: TargetMol
SKU: TMPY-01594
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: tumor necrosis factor, TNF-α) Copy Product Info

Synonyms: tumor necrosis factor, TNF-α

Catalog No. TMPY-01594 Copy Product Info

TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0.

Pack Size	Price	USA Stock	Global Stock
5 µg	$43	-	In Stock
10 µg	$68	-	In Stock
20 µg	$109	7-10 days	7-10 days
50 µg	$245	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:> 96 % as determined by SDS-PAGE

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 0.01-0.08 ng/ml.
Description	TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0.
Species	Canine
Expression System	E. coli
Tag	Tag Free
Accession Number	A9LMQ0
Construction	A DNA sequence encoding the soluble form of canine TNFα (NP_001003244.4) (Val 77-Leu 233) was expressed, with an initial Met at the N-terminus. Predicted N terminal: Met
Protein Purity	> 96 % as determined by SDS-PAGE
Endotoxin	Please contact us for more information.
Formulation	Supplied as sterile 50 mM Tris, 500 mM NaCl, 20% glycerol, pH 8.0.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	tumor necrosis factor, TNF-α
Research Background	Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.TNF-alpha Protein & AntibodyCancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

17.3 kDa (predicted); 17 kDa (reducing conditions)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.