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Piclamilast

Name: Piclamilast
Brand: TargetMol
SKU: T23154
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23154Cas No. 144035-83-6

Alias RPR 73401, RP 73401

Piclamilast (RP 73401) is a PDE4 inhibitor.

Piclamilast

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Purity: 99.57%

Catalog No. T23154Alias RPR 73401, RP 73401Cas No. 144035-83-6

Piclamilast (RP 73401) is a PDE4 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$529	In Stock	In Stock
100 mg	$753	-	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Piclamilast (RP 73401) is a PDE4 inhibitor.
Targets&IC50	PDE2:40 μM, PDE3:>100 μM, PDE1:>100 μM, PDE5:14 μM, PDE4:16 nM (pig aorta), PDE4:2 nM (eosinophil soluble)
In vitro	Piclamilast pre-treatment significantly inhibited the changes in 23 genes via mechanisms involving AP-1 activation and c-Jun phosphorylation at Ser63[1]. The IC50s for Piclamilast was 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively. Piclamilast exhibited IC50 values >100 μM, 40 μM, >100 μM, 14 μM for PDE1, PDE2, PDE3 and PDE5. Respectively[4].
In vivo	Initial in vivo studies conducted in severe combined immunodeficiency mice transplanted with NB4 leukemia cells indicate that the enhancing effect of piclamilast on ATRA-induced myeloid maturation translates into a therapeutic benefit[2].
Synonyms	RPR 73401, RP 73401

Chemical Properties

Molecular Weight	381.25
Formula	C₁₈H₁₈Cl₂N₂O₃
Cas No.	144035-83-6
Smiles	COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Relative Density.	1.37g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (78.69 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6230 mL	13.1148 mL	26.2295 mL	131.1475 mL
5 mM	0.5246 mL	2.6230 mL	5.2459 mL	26.2295 mL
10 mM	0.2623 mL	1.3115 mL	2.6230 mL	13.1148 mL
20 mM	0.1311 mL	0.6557 mL	1.3115 mL	6.5574 mL
50 mM	0.0525 mL	0.2623 mL	0.5246 mL	2.6230 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc