HLA-A*11:01&B2M&KRAS G12S (VVVGASGVGK) Monomer Protein, Human, MHC (His & Avi)

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

Pack Size	Availability	Price/USD	Quantity
100 μg	Inquiry	$ 146.00
1 mg	Inquiry	$ 979.00

Pack Size

Availability

Price/USD

Quantity

100 μg

Inquiry

$ 146.00

1 mg

Inquiry

$ 979.00

Description

Species	Human
Expression System	HEK293
Tag	C-His-Avi
Accession Number	AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGASGVGK
Synonyms	C-K-RAS, KRAS, RASK2, K-Ras 2, K-RAS2A, MHC, CFC2, K-RAS4B, K-RAS2B, RALD, NS3, GTPase Kras, KRAS1, KRAS2, K-RAS4A, NS, KI-RAS
Construction	Recombinant Human HLA-A11:01&B2M&KRAS G12S (VVVGASGVGK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Gly25-Thr305(HLA-A11:01), Ile21-Met119(B2M) and VVVGASGVGK peptide.[Accession \|AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGASGVGK]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage	-20 to -80°C for 12 months as supplied from date of receipt.-20 to -80°C for 3-6 months in unopened state after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.