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K-80003

🥰Excellent
Catalog No. T11734Cas No. 1292821-90-9
Alias TX-803

K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.

K-80003

K-80003

🥰Excellent
Purity: 99.76%
Catalog No. T11734Alias TX-803Cas No. 1292821-90-9
K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$38In StockIn Stock
5 mg$64In StockIn Stock
10 mg$101In StockIn Stock
25 mg$178In StockIn Stock
50 mg$272In StockIn Stock
100 mg$400In StockIn Stock
200 mg$569-In Stock
1 mL x 10 mM (in DMSO)$70In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.76%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.
In vitro
In MCF-7 cells, cotreatment with K-80003 inhibits the TNFα-induced colocalization of tRXRα with p85α in the cytoplasm, leading to tRXRα nuclear localization. Western blotting reveals that the K-80003-stabilized tetrameric form of tRXRα is exclusively present in the nuclear fraction, while the tRXRα monomer is distributed in both nuclear and cytoplasmic fractions [1].
In vivo
K-80003, a potent inhibitor of AKT activation by all-trans-retinoic acid, exhibits enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity for RXRα but lacks COX inhibitory activity [2].
SynonymsTX-803
Chemical Properties
Molecular Weight336.4
FormulaC22H21FO2
Cas No.1292821-90-9
SmilesCC(C)c1ccc(\C=C2\C(C)=C(CC(O)=O)c3cc(F)ccc23)cc1
Relative Density.1.192 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (178.36 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (7.43 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9727 mL14.8633 mL29.7265 mL148.6326 mL
5 mM0.5945 mL2.9727 mL5.9453 mL29.7265 mL
10 mM0.2973 mL1.4863 mL2.9727 mL14.8633 mL
20 mM0.1486 mL0.7432 mL1.4863 mL7.4316 mL
50 mM0.0595 mL0.2973 mL0.5945 mL2.9727 mL
100 mM0.0297 mL0.1486 mL0.2973 mL1.4863 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TX803TX 803RXRretinoid X receptor αRARK-80003K80003K 80003Akt
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