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Varespladib methyl

Name: Varespladib methyl
Brand: TargetMol
SKU: T17218
Price: 119 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17218Cas No. 172733-08-3

Alias LY333013, A-002

Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.

Varespladib methyl

🥰Excellent

Purity: 99.97%

Catalog No. T17218Alias LY333013, A-002Cas No. 172733-08-3

Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.

Pack Size	Price	Availability
1 mg	$119	In Stock
5 mg	$297	In Stock
10 mg	$478	In Stock
25 mg	$789	In Stock
50 mg	$1,080	In Stock
100 mg	$1,480	In Stock
500 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$445	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.97%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.
In vitro	Varespladib methyl display high-level secretory PLA2 inhibition at nanomolar and picomolar concentrations against 28 medically important snake venoms from six continents [1].
Synonyms	LY333013, A-002

Chemical Properties

Molecular Weight	394.42
Formula	C₂₂H₂₂N₂O₅
Cas No.	172733-08-3
Smiles	C(C(N)=O)(=O)C=1C=2C(N(CC3=CC=CC=C3)C1CC)=CC=CC2OCC(OC)=O
Relative Density.	1.26 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (240.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5354 mL	12.6768 mL	25.3537 mL	126.7684 mL
5 mM	0.5071 mL	2.5354 mL	5.0707 mL	25.3537 mL
10 mM	0.2535 mL	1.2677 mL	2.5354 mL	12.6768 mL
20 mM	0.1268 mL	0.6338 mL	1.2677 mL	6.3384 mL
50 mM	0.0507 mL	0.2535 mL	0.5071 mL	2.5354 mL
100 mM	0.0254 mL	0.1268 mL	0.2535 mL	1.2677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc