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MAO-B-IN-47

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Catalog No. T212519Cas No. 67082-01-3

MAO-B-IN-47 is a selective inhibitor of monoamine oxidase B (MAO-B) with a Ki value of 875 nM. It exhibits an IC50 value of over 100 μM in SH-SY5Y cells and demonstrates neuroprotective effects in SH-SY5Y cells treated with 6-hydroxydopamine. MAO-B-IN-47 is applicable in research on neurological disorders such as Parkinson's disease (PD).

MAO-B-IN-47

MAO-B-IN-47

😃Good
Catalog No. T212519Cas No. 67082-01-3
MAO-B-IN-47 is a selective inhibitor of monoamine oxidase B (MAO-B) with a Ki value of 875 nM. It exhibits an IC50 value of over 100 μM in SH-SY5Y cells and demonstrates neuroprotective effects in SH-SY5Y cells treated with 6-hydroxydopamine. MAO-B-IN-47 is applicable in research on neurological disorders such as Parkinson's disease (PD).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
MAO-B-IN-47 is a selective inhibitor of monoamine oxidase B (MAO-B) with a Ki value of 875 nM. It exhibits an IC50 value of over 100 μM in SH-SY5Y cells and demonstrates neuroprotective effects in SH-SY5Y cells treated with 6-hydroxydopamine. MAO-B-IN-47 is applicable in research on neurological disorders such as Parkinson's disease (PD).
Targets&IC50
MAO-B:875 nM (Ki)
In vitro
MAO-B-IN-47 (Compound 5a) shows no significant inhibitory effect on the proliferation of normal cells (hSDFs, AT-MSCs) or cancer cells (A-375, U87-MG, SH-SY5Y) when tested at concentrations of 0-40 μM. Additionally, MAO-B-IN-47 exhibits neuroprotective effects in 6-hydroxydopamine-treated SH-SY5Y cells at concentrations between 12.5-100 μM for 2 hours.
Chemical Properties
Molecular Weight278.27
FormulaC16H13F3O
Cas No.67082-01-3
SmilesO=C(C1=CC=CC(=C1)C(F)(F)F)CCC=2C=CC=CC2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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