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EGFR-IN-5

Name: EGFR-IN-5
Brand: TargetMol
SKU: T11160
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11160Cas No. 2225887-26-1

EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively.

EGFR-IN-5

🥰Excellent

Purity: 98.17%

Catalog No. T11160Cas No. 2225887-26-1

EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively.

Pack Size	Price	Availability
1 mg	$107	In Stock
5 mg	$263	In Stock
10 mg	$419	In Stock
25 mg	$793	In Stock
1 mL x 10 mM (in DMSO)	$332	In Stock

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Batch Information

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Purity:98.17%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively.
Targets&IC50	EGFR:10.4 nM, EGFR (L858R/T790M/C797S):7.2 nM, EGFR (L858R/T790M):34 nM, EGFR (L858R):1.1 nM

Chemical Properties

Molecular Weight	571.69
Formula	C₃₁H₃₈FN₉O
Cas No.	2225887-26-1
Smiles	N(C=1N=C(C2=C(N1)C=NC(NC3=CC=C(C=N3)N4CCC(N(C)C)CC4)=C2)N5CCC(CO)CC5)C6=CC=C(F)C=C6
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (209.90 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7492 mL	8.7460 mL	17.4920 mL	87.4600 mL
5 mM	0.3498 mL	1.7492 mL	3.4984 mL	17.4920 mL
10 mM	0.1749 mL	0.8746 mL	1.7492 mL	8.7460 mL
20 mM	0.0875 mL	0.4373 mL	0.8746 mL	4.3730 mL
50 mM	0.0350 mL	0.1749 mL	0.3498 mL	1.7492 mL
100 mM	0.0175 mL	0.0875 mL	0.1749 mL	0.8746 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc