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MitoBloCK-6

🥰Excellent
Catalog No. T60143Cas No. 303215-67-0

MitoBloCK-6 is a potent Erv1/ALR inhibitor with IC50 values of 900 nM and 700 nM, respectively, and also inhibits Erv2 with an IC50 of 1.4 μM. Additionally, MitoBloCK-6 can induce apoptosis via cytochrome c release in human embryonic stem cells (hESCs) [1].

MitoBloCK-6

MitoBloCK-6

🥰Excellent
Purity: 99.97%
Catalog No. T60143Cas No. 303215-67-0
MitoBloCK-6 is a potent Erv1/ALR inhibitor with IC50 values of 900 nM and 700 nM, respectively, and also inhibits Erv2 with an IC50 of 1.4 μM. Additionally, MitoBloCK-6 can induce apoptosis via cytochrome c release in human embryonic stem cells (hESCs) [1].
Pack SizePriceAvailabilityQuantity
5 mg$33In Stock
10 mg$47In Stock
25 mg$76In Stock
50 mg$126In Stock
100 mg$197In Stock
200 mg$297In Stock
500 mg$516In Stock
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Purity:99.97%
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Product Introduction

Bioactivity
Description
MitoBloCK-6 is a potent Erv1/ALR inhibitor with IC50 values of 900 nM and 700 nM, respectively, and also inhibits Erv2 with an IC50 of 1.4 μM. Additionally, MitoBloCK-6 can induce apoptosis via cytochrome c release in human embryonic stem cells (hESCs) [1].
Chemical Properties
Molecular Weight357.23
FormulaC19H14Cl2N2O
Cas No.303215-67-0
SmilesOc1c(Cl)cc(Cl)cc1\C=N\c1ccc(Nc2ccccc2)cc1
Relative Density.1.28 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (139.97 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7993 mL13.9966 mL27.9932 mL139.9658 mL
5 mM0.5599 mL2.7993 mL5.5986 mL27.9932 mL
10 mM0.2799 mL1.3997 mL2.7993 mL13.9966 mL
20 mM0.1400 mL0.6998 mL1.3997 mL6.9983 mL
50 mM0.0560 mL0.2799 mL0.5599 mL2.7993 mL
100 mM0.0280 mL0.1400 mL0.2799 mL1.3997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MitoBloCK-6MitoBloCK6Apoptosis
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