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Anti-ABP1/AOC1 Antibody (4P152) is a Mouse antibody targeting ABP1/AOC1. Anti-ABP1/AOC1 Antibody (4P152) can be used in ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $198 | 7-10 days |
Description | Anti-ABP1/AOC1 Antibody (4P152) is a Mouse antibody targeting ABP1/AOC1. Anti-ABP1/AOC1 Antibody (4P152) can be used in ELISA. |
Alias | KAO, DAO1, DAO, amine oxidase, copper containing 1, ABP1, ABP |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 4P152 |
Reactivity | Human |
Application | ELISA |
Recommended Dose | ELISA: 1:1000-1:2000 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ABP1/AOC1 (rh ABP1/AOC1; TMPY-00140; AAH14093.1; Met1-Val751). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under control of the proximal AOC1 promoter was significantly enhanced by co-transfection of a WT1 expression construct. Binding of WT1 protein to a cis-regulatory element in the AOC1 promoter was confirmed by electrophoretic mobility shift assay and chromatin immunoprecipitation. WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis. |
Conjucates | Unconjugated |
Immunogen | Recombinant Human ABP1/AOC1 Protein (TMPY-00140) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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