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MnTBAP chloride

Name: MnTBAP chloride
Brand: TargetMol
SKU: T38164
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38164Cas No. 55266-18-7

Alias Mn(III)TBAP

MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs).

MnTBAP chloride

🥰Excellent

Catalog No. T38164Alias Mn(III)TBAPCas No. 55266-18-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$40	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs).
In vitro	Due to its superoxide dismutase mimetic property, 50 microM MnTBAP was found to attenuate the injury produced dose-dependently by exposure to various concentrations of paraquat for 4 h. MnTBAP also protected endothelial cells in a dose-dependent manner against paraquat. The protective effect of MnTBAP appears to be caused by its intracellular superoxide-scavenging activity because neither the zinc form nor CuZnSOD protected the cells against paraquat-induced injury.[1]
In vivo	Local administration of MnTBAP significantly and reduced carrageenan-induced paw oedema dose-dependently at all time points, which was related to its superoxide dismutase mimetic property. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity, as well as preventing histological injury. Immunohistochemical analyses for nitrotyrosine showed a positive staining in paw from carrageenan-treated rats.[2]
Synonyms	Mn(III)TBAP

Chemical Properties

Molecular Weight	876.13
Formula	C₄₈H₂₅ClMnN₄O₈
Cas No.	55266-18-7
Smiles	[H+].O=C([O-])C=1C=CC(=CC1)C2=C3C=CC=4C(C=5C=CC(=CC5)C(=O)[O-])=C6C=CC7=C(C8=CC=C(C=C8)C(=O)[O-])C=9C=CC%10=C(C%11=CC=C(C=C%11)C(=O)[O-])C%12=CC=C2[N-]%12[Mn+3]([Cl-])([N]34)([N]%109)[N-]67

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (102.4 mM), Sonication is recommended.

0.5 M NaOH: 18.0 mg/mL (20.5 mM), Sonication is recommended.

1M NaOH: 9.0 mg/mL (10.2 mM), when pH is adjusted to 8 with NaOH. Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (4.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

1M NaOH/0.5 M NaOH/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1414 mL	5.7069 mL	11.4138 mL	57.0692 mL
5 mM	0.2283 mL	1.1414 mL	2.2828 mL	11.4138 mL
10 mM	0.1141 mL	0.5707 mL	1.1414 mL	5.7069 mL

0.5 M NaOH/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0571 mL	0.2853 mL	0.5707 mL	2.8535 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0228 mL	0.1141 mL	0.2283 mL	1.1414 mL
100 mM	0.0114 mL	0.0571 mL	0.1141 mL	0.5707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc