Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 34.00 | |
25 mg | In stock | $ 55.00 | |
50 mg | In stock | $ 82.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs). |
In vitro | Due to its superoxide dismutase mimetic property, 50 microM MnTBAP was found to attenuate the injury produced dose-dependently by exposure to various concentrations of paraquat for 4 h. MnTBAP also protected endothelial cells in a dose-dependent manner against paraquat. The protective effect of MnTBAP appears to be caused by its intracellular superoxide-scavenging activity because neither the zinc form nor CuZnSOD protected the cells against paraquat-induced injury.[1] |
In vivo | Local administration of MnTBAP significantly and reduced carrageenan-induced paw oedema dose-dependently at all time points, which was related to its superoxide dismutase mimetic property. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity, as well as preventing histological injury. Immunohistochemical analyses for nitrotyrosine showed a positive staining in paw from carrageenan-treated rats.[2] |
Synonyms | Mn(III)TBAP |
Molecular Weight | 876.13 |
Formula | C48H25ClMnN4O8 |
CAS No. | 55266-18-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (102.4 mM), Sonication is recommended.
0.5 M NaOH: 18.0 mg/mL (20.5 mM), Sonication is recommended.
1M NaOH: 9.0 mg/mL (10.2 mM), when pH is adjusted to 8 with NaOH. Sonication is recommended.
You can also refer to dose conversion for different animals. More
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MnTBAP chloride 55266-18-7 Mn(III)TBAP MnTBAP Chloride inhibitor inhibit