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Glabrol

Name: Glabrol
Brand: TargetMol
SKU: TN1691
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1691Cas No. 59870-65-4

5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.

Glabrol

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Purity: 99.72%

Catalog No. TN1691Cas No. 59870-65-4

5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.

Pack Size	Price	Availability
1 mg	$73	In Stock
5 mg	$197	In Stock
10 mg	$347	In Stock
25 mg	$577	In Stock
1 mL x 10 mM (in DMSO)	$223	In Stock

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Batch Information

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Purity:99.72%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. It is an epigenetic modification formed by the action of DNA methyltransferases.
Targets&IC50	ACAT (rat):24.6 μM (IC50)
In vitro	Based on the bioactivities of licorice, these compounds were screened using cell- or enzyme-based bioassay methods. A total of 11 compounds exhibited potent cytotoxic activities against three human cancer cell lines (HepG2, SW480 and MCF7), while showed little toxicity on human normal cell lines LO2 and HEK293T[1]

Chemical Properties

Molecular Weight	392.49
Formula	C₂₅H₂₈O₄
Cas No.	59870-65-4
Smiles	CC(C)=CCc1cc(ccc1O)[C@@H]1CC(=O)c2ccc(O)c(CC=C(C)C)c2O1
Relative Density.	1.166g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (165.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5478 mL	12.7392 mL	25.4784 mL	127.3918 mL
5 mM	0.5096 mL	2.5478 mL	5.0957 mL	25.4784 mL
10 mM	0.2548 mL	1.2739 mL	2.5478 mL	12.7392 mL
20 mM	0.1274 mL	0.6370 mL	1.2739 mL	6.3696 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL	2.5478 mL
100 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc