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Dihydrocoumarin

🥰Excellent
Catalog No. T2S0300Cas No. 119-84-6
Alias melilotin, Hydrocoumarin, Chroman-2-one, 3,4-dihydrocoumarin, 2-chromanone

Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

Dihydrocoumarin

Dihydrocoumarin

🥰Excellent
Purity: 98.46%
Catalog No. T2S0300Alias melilotin, Hydrocoumarin, Chroman-2-one, 3,4-dihydrocoumarin, 2-chromanoneCas No. 119-84-6
Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
Pack SizePriceAvailabilityQuantity
10 g$29In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:98.46%
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Product Introduction

Bioactivity
Description
Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
Targets&IC50
SIRT2 (human):295 μM, SIRT1 (human):208 μM
Synonymsmelilotin, Hydrocoumarin, Chroman-2-one, 3,4-dihydrocoumarin, 2-chromanone
Chemical Properties
Molecular Weight148.16
FormulaC9H8O2
Cas No.119-84-6
SmilesO=C1CCC2=C(O1)C=CC=C2
Relative Density.1.169 g/cm3 at 25℃ (lit.)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (74.24 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.7495 mL33.7473 mL67.4946 mL337.4730 mL
5 mM1.3499 mL6.7495 mL13.4989 mL67.4946 mL
10 mM0.6749 mL3.3747 mL6.7495 mL33.7473 mL
20 mM0.3375 mL1.6874 mL3.3747 mL16.8737 mL
50 mM0.1350 mL0.6749 mL1.3499 mL6.7495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SirtuinSIRT2SIRT1InhibitorinhibitDihydrocoumarin
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