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Oxamflatin

Name: Oxamflatin
Brand: TargetMol
SKU: T16415
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16415Cas No. 151720-43-3

Alias Metacept-3

Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor characterized by high potency (IC50 = 15.7 nM) and the presence of an alkyne group capable of undergoing azide-alkyne cycloaddition reactions (CuAAc).

Oxamflatin

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Purity: 98.25%

Catalog No. T16415Alias Metacept-3Cas No. 151720-43-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	$239	In Stock	In Stock
25 mg	$529	In Stock	In Stock
50 mg	$745	In Stock	In Stock
100 mg	$977	-	In Stock
200 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.25%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor characterized by high potency (IC50 = 15.7 nM) and the presence of an alkyne group capable of undergoing azide-alkyne cycloaddition reactions (CuAAc).
Targets&IC50	HDAC:15.7 nM
In vitro	Methods: HeLa cells were cultured for 24 hours, and 1 mg/ml of Oxamflatin (Metacept-3) was added to the cultures at 0 hours. After the indicated incubation times, cells were harvested and their isolated nuclei were analyzed by flow cytometry; the distribution of cells in the cell cycle was determined using ModFit LT software. Results: Oxamflatin caused HeLa cells to have an elongated cell shape with filamentous processes and cell cycle arrest in the G1 phase. [1]
In vivo	Methods: Oxamflatin (Metacept-3) (8±50 mg/kg, intraperitoneal injection) was used in mice with B16 melanoma cell tumor xenografts at days 1, 3, 5, 7, 9, and 11 after inoculation. The increase in lifespan (ILS) of mice transplanted with B16 murine melanoma tumors after treatment with oxam¯atin was measured, and the number of days of survival was calculated and the ILS% was calculated. Results: Six injections of oxamflatin at a dose of 20 mg/kg each time significantly increased the number of days of survival of mice (38% of ILS); the ILS of mice treated with 50 mg/kg of oxamflatin was calculated to be over 67%, and one mouse survived for more than 60 days after tumor inoculation. No side effects such as weight loss were observed, at least until this dose. [1]
Synonyms	Metacept-3

Chemical Properties

Molecular Weight	342.37
Formula	C₁₇H₁₄N₂O₄S
Cas No.	151720-43-3
Smiles	N(S(=O)(=O)C1=CC=CC=C1)C2=CC(C#C/C=C/C(NO)=O)=CC=C2
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (365.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9208 mL	14.6041 mL	29.2082 mL	146.0408 mL
5 mM	0.5842 mL	2.9208 mL	5.8416 mL	29.2082 mL
10 mM	0.2921 mL	1.4604 mL	2.9208 mL	14.6041 mL
20 mM	0.1460 mL	0.7302 mL	1.4604 mL	7.3020 mL
50 mM	0.0584 mL	0.2921 mL	0.5842 mL	2.9208 mL
100 mM	0.0292 mL	0.1460 mL	0.2921 mL	1.4604 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc