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TRPM8 antagonist WS-3

Name: TRPM8 antagonist WS-3
Brand: TargetMol
SKU: T5962
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5962Cas No. 39711-79-0

Alias N-Ethyl-p-menthane-3-carboxamide, N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, Cyclohexanecarboxamide

TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).

TRPM8 antagonist WS-3

🥰Excellent

Purity: 97.64%

Catalog No. T5962Alias N-Ethyl-p-menthane-3-carboxamide, N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, CyclohexanecarboxamideCas No. 39711-79-0

TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).

Pack Size	Price	Availability	Quantity
1 g	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:97.64%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).
Targets&IC50	TRPM8:3.7 μM (EC50)
Synonyms	N-Ethyl-p-menthane-3-carboxamide, N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, Cyclohexanecarboxamide

Chemical Properties

Molecular Weight	211.34
Formula	C₁₃H₂₅NO
Cas No.	39711-79-0
Smiles	C(NCC)(=O)C1C(C(C)C)CCC(C)C1
Relative Density.	0.9305 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (473.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7317 mL	23.6586 mL	47.3171 mL	236.5856 mL
5 mM	0.9463 mL	4.7317 mL	9.4634 mL	47.3171 mL
10 mM	0.4732 mL	2.3659 mL	4.7317 mL	23.6586 mL
20 mM	0.2366 mL	1.1829 mL	2.3659 mL	11.8293 mL
50 mM	0.0946 mL	0.4732 mL	0.9463 mL	4.7317 mL
100 mM	0.0473 mL	0.2366 mL	0.4732 mL	2.3659 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc