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Vc-seco-DUBA

Name: Vc-seco-DUBA
Brand: TargetMol
SKU: T18362
Rating: 4.5 (1 reviews)

Catalog No. T18362 Copy Product Info

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Vc-seco-DUBA (Duocarmazine) is a linker-payload conjugate designed for the synthesis of Antibody-Drug Conjugates (ADCs). It consists of the potent DNA alkylating payload DUBA (a duocarmycin analog) connected via the Vc-seco linker. This conjugate is engineered to enable the targeted delivery of highly cytotoxic DNA-alkylating agents specifically to tumor cells through antibody guidance. DUBA exerts its effect by binding to the minor groove of DNA and causing alkylation, which leads to DNA damage and subsequent apoptosis, demonstrating potent antitumor efficacy.

Vc-seco-DUBA

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Catalog No. T18362

Cas No. 1345681-58-4

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$754	7-10 days	7-10 days
5 mg	$3,570	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	1331.81
Formula	C₆₅H₇₅ClN₁₂O₁₇
Cas No.	1345681-58-4
Smiles	C(Cl)[C@H]1C2=C(N(C(=O)C=3N=C4N(C3)C=C(NC(=O)C5=CC=C(O)C=C5)C=C4)C1)C=C(OC(N(CCN(C(OCC6=CC=C(NC([C@@H](NC([C@@H](NC(OCCOCCN7C(=O)C=CC7=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C6)=O)C)CCOCCO)=O)C=8C2=C(C)C=CC8
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (60.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7509 mL	3.7543 mL	7.5086 mL	37.5429 mL
5 mM	0.1502 mL	0.7509 mL	1.5017 mL	7.5086 mL
10 mM	0.0751 mL	0.3754 mL	0.7509 mL	3.7543 mL
20 mM	0.0375 mL	0.1877 mL	0.3754 mL	1.8771 mL
50 mM	0.0150 mL	0.0751 mL	0.1502 mL	0.7509 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

Calculator

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Dilution Calculator
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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc