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Methiothepin mesylate

Name: Methiothepin mesylate
Brand: TargetMol
SKU: T2190
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2190Cas No. 74611-28-2

Alias Ro 8-6837 mesylate, Metitepine mesylate

Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic.

Methiothepin mesylate

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Purity: 99.92%

Catalog No. T2190Alias Ro 8-6837 mesylate, Metitepine mesylateCas No. 74611-28-2

Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$50	In Stock	In Stock
25 mg	$78	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Color:White

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Product Introduction

Methiothepin mesylate AI Summary

Methiothepin mesylate exhibits a broad spectrum of bioactivities spanning antiplasmodial, antiviral, modulatory, and inhibitory properties. It shows antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 5011.87 nM to 12589.25 nM as determined by the SYBR green assay after 72 hours. This compound is also a differential inhibitor of Plasmodium falciparum proliferation and demonstrates antiviral activities, particularly against SARS-CoV-2, by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease with a 5.834% inhibition at 20µM concentration. Methiothepin mesylate acts as a serotonergic receptor antagonist at 5-HT1A and 5-HT2A receptors, significantly inhibiting serotonin-induced calcium flux with IC50 values of 71.0 nM and 56.0 nM, respectively. It possesses modulatory effects on Lamin A splicing, SMN2 splice variant expression, and multiple signaling pathways, including ERK and TGF-β. The compound exhibits inhibition of other targets like Tyrosyl-DNA Phosphodiesterase (TDP1), Tau fibril formation, JMJD2A-Tudor domain, Nrf2, UBC13 Polyubiquitin interactions, MPP8 Chromodomain interactions, and Human Flap endonuclease 1 (FEN1). It also has implications in the treatment of Gaucher Disease by influencing glucocerebrosidase activity and inducing synthetic lethality in tumor cells. Furthermore, Methiothepin mesylate serves as a tool in high-throughput screenings for inhibitors of RAD52, AMA1-RON, and antimalarial drug development, indicating its broad potential in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic.
Synonyms	Ro 8-6837 mesylate, Metitepine mesylate

Chemical Properties

Molecular Weight	452.65
Formula	C₂₁H₂₈N₂O₃S₃
Cas No.	74611-28-2
Smiles	CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (99.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2092 mL	11.0461 mL	22.0921 mL	110.4606 mL
5 mM	0.4418 mL	2.2092 mL	4.4184 mL	22.0921 mL
10 mM	0.2209 mL	1.1046 mL	2.2092 mL	11.0461 mL
20 mM	0.1105 mL	0.5523 mL	1.1046 mL	5.5230 mL
50 mM	0.0442 mL	0.2209 mL	0.4418 mL	2.2092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc