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[11C]MP 10

🥰Excellent
Catalog No. T6042Cas No. 1292799-56-4
Alias PF-2545920, Mardepodect

[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.

[11C]MP 10
Other Forms of [11C]MP 10:

[11C]MP 10

🥰Excellent
Purity: 99.5%
Catalog No. T6042Alias PF-2545920, MardepodectCas No. 1292799-56-4
[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.
Pack SizePriceAvailabilityQuantity
1 mg$55In Stock
2 mg$98In Stock
5 mg$202In Stock
10 mg$279In Stock
25 mg$455In Stock
50 mg$669In Stock
1 mL x 10 mM (in DMSO)$216In Stock
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Batch Information

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Purity:99.5%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.
Targets&IC50
PDE10A:0.37 nM
In vitro
PF-2545920 shows excellent potency and specificity in PDE10A with IC50 of 1.26 nM.
SynonymsPF-2545920, Mardepodect
Chemical Properties
Molecular Weight391.45
FormulaC25H20N4O
Cas No.1292799-56-4
Smiles[11CH3]N1N=C(C(=C1)C=2C=CN=CC2)C3=CC=C(OCC4=NC5=C(C=C4)C=CC=C5)C=C3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 69 mg/mL (176.27 mM), Sonication is recommended.
DMSO: 79 mg/mL (201.81 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.5546 mL12.7730 mL25.5460 mL127.7302 mL
5 mM0.5109 mL2.5546 mL5.1092 mL25.5460 mL
10 mM0.2555 mL1.2773 mL2.5546 mL12.7730 mL
20 mM0.1277 mL0.6387 mL1.2773 mL6.3865 mL
50 mM0.0511 mL0.2555 mL0.5109 mL2.5546 mL
100 mM0.0255 mL0.1277 mL0.2555 mL1.2773 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PF2545920PF 2545920PDE10A[11C]MP 10
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