Shopping Cart

Your shopping cart is currently empty

SP-8356

Name: SP-8356
Brand: TargetMol
SKU: T12981
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Synonyms:

Catalog No. T12981 Copy Product Info

Purity: 98.24%

😃Good

SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.

Cas No. 1454885-45-0

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
1 mg	$64	In Stock	In Stock
5 mg	$158	In Stock	In Stock
10 mg	$250	In Stock	In Stock
25 mg	$473	In Stock	In Stock
50 mg	$642	In Stock	In Stock
100 mg	$858	In Stock	In Stock
200 mg	$1,160	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:98.24%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.
In vitro	In a time- and dose-dependent manner, SP-8356 (5-10 μM; 48 hours) inhibits the growth of various types of breast cancer cell lines. SP-8356 (10 μM; 48 hours) increases the percentage of MDA-MB231 cells in the S phase and decreases caspase-3 and cleaved PARP [1].
In vivo	In a xenograft mouse model, SP-8356 (10mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth [1]. SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability [2].

Chemical Properties

Molecular Weight	300.35
Formula	C₁₈H₂₀O₄
Cas No.	1454885-45-0
Smiles	C(=C/C1=CC(OC)=C(O)C(O)=C1)\C=2[C@]3(C(C)(C)[C@](C3)(C(=O)C2)[H])[H]
Relative Density.	1.303 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (208.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 6.25 mg/mL (20.81 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3294 mL	16.6472 mL	33.2945 mL	166.4724 mL
5 mM	0.6659 mL	3.3294 mL	6.6589 mL	33.2945 mL
10 mM	0.3329 mL	1.6647 mL	3.3294 mL	16.6472 mL
20 mM	0.1665 mL	0.8324 mL	1.6647 mL	8.3236 mL
50 mM	0.0666 mL	0.3329 mL	0.6659 mL	3.3294 mL
100 mM	0.0333 mL	0.1665 mL	0.3329 mL	1.6647 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc