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JNJ-40411813

Name: JNJ-40411813
Brand: TargetMol
SKU: TQ0094
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0094Cas No. 1127498-03-6

Alias ADX-71149

JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).

JNJ-40411813

🥰Excellent

Purity: 99.74%

Catalog No. TQ0094Alias ADX-71149Cas No. 1127498-03-6

JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).

Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$119	In Stock
10 mg	$193	In Stock
25 mg	$323	In Stock
50 mg	$461	In Stock
100 mg	$592	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

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Batch Information

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Purity:99.74%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
Targets&IC50	mGluR2:147 nM (EC50)
Synonyms	ADX-71149

Chemical Properties

Molecular Weight	344.88
Formula	C₂₀H₂₅ClN₂O
Cas No.	1127498-03-6
Smiles	CCCCn1ccc(N2CCC(CC2)c2ccccc2)c(Cl)c1=O
Relative Density.	1.18 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24 mg/mL (69.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8996 mL	14.4978 mL	28.9956 mL	144.9780 mL
5 mM	0.5799 mL	2.8996 mL	5.7991 mL	28.9956 mL
10 mM	0.2900 mL	1.4498 mL	2.8996 mL	14.4978 mL
20 mM	0.1450 mL	0.7249 mL	1.4498 mL	7.2489 mL
50 mM	0.0580 mL	0.2900 mL	0.5799 mL	2.8996 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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