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Membrane transporter/Ion channel

Monoamine Transporter

(18)

Monocarboxylate transporter

Na-K-Cl cotransporter

Sodium-dependent phosphate transporter

ATPase

ATPases ( adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, adenosine 5'-triphosphatase, ATP hydrolase, complex V (mitochondrial electron transport), (Ca2+ + Mg2+)-ATPase, HCO3−-ATPase, adenosine triphosphatase) are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion[1][2][3][4][5][6] or the inverse reaction. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur.

Filter HomeSignaling PathwaysMembrane transporter/Ion channelATPase

Brefeldin A

T606220350-15-6

Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.

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Tirofiban hydrochloride monohydrate

T2537150915-40-5

Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb IIIa antagonist.

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Bufalin

T1719465-21-4

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic a

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Oligomycin A

T6323579-13-5

Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.

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BMS-199264 hydrochloride

T26843186180-83-6

BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.

$118

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(-)-blebbistatin

T6038856925-71-8

(-)-Blebbistatin ((S)-(-)-Blebbistatin) is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM.

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Chebulinic acid

TQ018418942-26-2

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.

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Blebbistatin

T21550674289-55-5

Blebbistatin ((±)-Blebbistatin) is a non-muscle myosin II (NMII)-selective and non-muscle myosin heavy chain 9 (MYH9)-specific inhibitor that promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, while preserving the integrity of cell junctions and barrier function.

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FCCP

T6834370-86-5

FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.

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Cytochalasin D

T322922144-77-0

Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit

$347

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Oleic acid

T2O2668112-80-1

Oleic acid (Glycon Wo) is a natural product, a common monounsaturated fatty acid found in a variety of animal and vegetable fats and oils. Palmitic acid is a Na+ K+ ATPase activator.

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Cinobufagin

T3432470-37-1

Cinobufagin (Cinobufagine) is a selective Na+ K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.

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Gboxin

T153732101315-36-8

Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.

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Lanatoside C

T167017575-22-3

Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally or by the intravenous route.

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SKF96067

T16894115607-61-9In house

SKF96067 is a reversible gastric H+ K+-ATPase inhibitor that can induce relaxation of human airway smooth muscle in vitro.

$293

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Ginsenoside Rb1

T282241753-43-9

Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.

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Tiludronate disodium

T13159149845-07-8In house

Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.

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Strictosamide

TN223923141-25-5

Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.

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AGN-201904

T23667651729-53-2In house

AGN-201904 is an omeprazole prodrug and proton pump inhibitor, which may delay aging and be used for the prevention and treatment of peptic ulcers.

$293

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Sodium oleate

T36390143-19-1

Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na+ K+ ATPase activator.

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Licoflavone B

TN186091433-17-9

Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities.

$128

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NC-1300-B

T28136104340-52-5In house

NC-1300-B inhibits H(+)-K(+)-ATPase and is used in the study of gastric ulcers.

$293

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Digitoxin

T029571-63-6

Digitoxin (Digitoxinum) is an effective Na+ K+-ATPase inhibitor (EC50 value: 0.78 μM).

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Bacoside A3

TN1425157408-08-7

Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.

$140

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