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Anti-GAB1 Antibody (4I330)
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Catalog No. TMAC-01582
Alias Growth factor receptor bound protein 2-associated protein 1, GRB2-associated-binding protein 1, GRB2-associated binder 1, GRB2 associated binding protein 1 isoform b, GRB2 associated binding protein 1 isoform a, GRB 2 associated binding protein 1, GRB 2 associated binder 1, GAB1_HUMAN, GAB1, Gab 1
Anti-GAB1 Antibody (4I330) is a Rabbit antibody targeting GAB1. Anti-GAB1 Antibody (4I330) can be used in WB,ICC,IF,IHC,FCM.
Anti-GAB1 Antibody (4I330)
Anti-GAB1 Antibody (4I330)
😃Good
Catalog No. TMAC-01582Alias Growth factor receptor bound protein 2-associated protein 1, GRB2-associated-binding protein 1, GRB2-associated binder 1, GRB2 associated binding protein 1 isoform b, GRB2 associated binding protein 1 isoform a, GRB 2 associated binding protein 1, GRB 2 associated binder 1, GAB1_HUMAN, GAB1, Gab 1
Anti-GAB1 Antibody (4I330) is a Rabbit antibody targeting GAB1. Anti-GAB1 Antibody (4I330) can be used in WB,ICC,IF,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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| Description | Anti-GAB1 Antibody (4I330) is a Rabbit antibody targeting GAB1. Anti-GAB1 Antibody (4I330) can be used in WB,ICC,IF,IHC,FCM. |
| Synonyms | Growth factor receptor bound protein 2-associated protein 1, GRB2-associated-binding protein 1, GRB2-associated binder 1, GRB2 associated binding protein 1 isoform b, GRB2 associated binding protein 1 isoform a, GRB 2 associated binding protein 1, GRB 2 associated binder 1, GAB1_HUMAN, GAB1, Gab 1 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of GAB1 on human small intestine tissue lysate using anti-GAB1 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-GAB1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-GAB1 antibody. Counter stained with hematoxylin. 4. ICC staining GAB1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining GAB1 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining GAB1 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of Hela cells with GAB1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:100-500; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 77 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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