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Anti-CD46 Monoclonal Antibody (8S536)
(Synonyms: TRA2.10, TLX, MIC10, MCP, AHUS2) Copy Product Info
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Synonyms: TRA2.10, TLX, MIC10, MCP, AHUS2
Catalog No. TMAT-0421 Copy Product Info
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Anti-CD46 Monoclonal Antibody (8S536) is a Mouse antibody targeting CD46. Anti-CD46 Monoclonal Antibody (8S536) can be used in WB,IF,FCM.
Anti-CD46 Monoclonal Antibody
(8S536)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-CD46 Monoclonal Antibody (8S536) is a Mouse antibody targeting CD46. Anti-CD46 Monoclonal Antibody (8S536) can be used in WB,IF,FCM. |
| Synonyms | TRA2.10, TLX, MIC10, MCP, AHUS2 |
| Ig Type | IgG1 |
| Clone | 8S536 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IF: 1/100-1/500; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | CD46 |
| Gene ID | |
| Protein Name | Membrane cofactor protein |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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