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Anti-BCL-XL Antibody (9W422)
😃Good
Catalog No. TMAY-02839
Alias Bcl-XL, bcl-x, BclX, BCL2-like 1, bcl2-L-1, Bcl2l, Bcl(X)L
Anti-BCL-XL Antibody (9W422) is a Mouse antibody targeting BCL-XL. Anti-BCL-XL Antibody (9W422) can be used in IHC-P.
Anti-BCL-XL Antibody (9W422)
Anti-BCL-XL Antibody (9W422)
😃Good
Catalog No. TMAY-02839Alias Bcl-XL, bcl-x, BclX, BCL2-like 1, bcl2-L-1, Bcl2l, Bcl(X)L
Anti-BCL-XL Antibody (9W422) is a Mouse antibody targeting BCL-XL. Anti-BCL-XL Antibody (9W422) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-BCL-XL Antibody (9W422) is a Mouse antibody targeting BCL-XL. Anti-BCL-XL Antibody (9W422) can be used in IHC-P. |
| Alias | Bcl-XL, bcl-x, BclX, BCL2-like 1, bcl2-L-1, Bcl2l, Bcl(X)L |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 9W422 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human BCL2L1 in human kidney with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human BCL2L1 in human gallbladder with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Produced in rabbits immunized with E. coli-derived Human Bcl-XL fragment, and purified by antigen affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apoptosis independent of additional signals. The crystal and solution structures of a Bcl-2 family member, Bcl-xL is like this: The structures consist of two central, primarily hydrophobic α-helices, which are surrounded by amphipathic helices. A 60-residue loop connecting helices αl and α2 was found to be flexible and non-essential for anti-apoptotic activity. Bcl-xL is characterized as an important factor in autophagy, inhibiting Beclin 1-mediated autophagy by binding to Beclin 1. In addition, Beclin 1, Bcl-2 and Bcl-xL can cooperate with Atg5 or Ca2+to regulate both autophagy and apoptosis. Bcl-xL is also implicated in anoxia induced cell death. The pathway is initiated by the loss of function of the prosurvival Bcl-2 family members Mcl-1 and Bcl-2 / Bcl-XL, resulting in Bax- or Bak-dependent release of cytochrome c and subsequent caspase-9-dependent cell death. Thus, Bcl-xL, the well-characterized apoptosis guards, appears to be important in cell death. |
| Conjucates | Unconjugated |
| Immunogen | E. coli-derived Human Bcl-XL fragment |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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