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Vercirnon

Name: Vercirnon
Brand: TargetMol
SKU: T17225
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17225Cas No. 698394-73-9

Alias Traficet-EN, GSK-1605786, CCX282-B

Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.

Vercirnon

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Purity: 99.23%

Catalog No. T17225Alias Traficet-EN, GSK-1605786, CCX282-BCas No. 698394-73-9

Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$107	In Stock	In Stock
5 mg	$272	In Stock	In Stock
10 mg	$428	In Stock	In Stock
25 mg	$716	In Stock	In Stock
50 mg	$987	In Stock	In Stock
100 mg	$1,370	In Stock	In Stock
500 mg	$2,730	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$382	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.23%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
Targets&IC50	CCR9:10 nM
In vitro	Vercirnon is also a potent inhibitor of CCL25-induced Molt-4 chemotaxis (IC50: 3.5 ± 0.3 nM). Vercirnon inhibits CCL25-induced calcium mobilization (IC50: 5.4 ± 0.7 nM). Vercirnon inhibits the chemotaxis of Baf-3/CCR9A cells as well as Baf-3/CCR9A cells (IC50s: 2.8 ± 1.1 nM and 2.6 ± 0.7 nM, respectively). Vercirnon potently inhibits CCL25-induced chemotaxis (IC50: 6.8 ± 1.7 nM in the buffer) and exhibits inhibition on RA-cultured cell CCL25-medidated chemotaxis in 100% human AB serum (IC50: 141 ± 13 nM). Vercirnon shows inhibitory activity against Molt-4 migration (IC50: 33.4 ± 1.3 nM in 100% human AB serum). Vercirnon suppresses the binding of [3H] CCX807 to Molt-4 cells (IC50: 6 nM) [1].
In vivo	Vercirnon (50?mg/kg c.c. twice daily) blocks the colitis-associated weight loss inherent in the mdr1a?/? model and also abrogates growth arrest in the colitis mdr1a ?/? mice. Vercirnon (10, 50 mg/kg twice daily) protects from the severe inflammation associated with TNF-α overexpression in the TNFΔARE Mouse Model [2].
Synonyms	Traficet-EN, GSK-1605786, CCX282-B

Chemical Properties

Molecular Weight	444.93
Formula	C₂₂H₂₁ClN₂O₄S
Cas No.	698394-73-9
Smiles	CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)cc1C(=O)c1cc[n+]([O-])cc1
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (33.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (3.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2475 mL	11.2377 mL	22.4754 mL	112.3772 mL
5 mM	0.4495 mL	2.2475 mL	4.4951 mL	22.4754 mL
10 mM	0.2248 mL	1.1238 mL	2.2475 mL	11.2377 mL
20 mM	0.1124 mL	0.5619 mL	1.1238 mL	5.6189 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc