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HPK1-IN-7

Name: HPK1-IN-7
Brand: TargetMol
SKU: T9470
Price: 77 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9470Cas No. 2320462-65-3

HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).

HPK1-IN-7

🥰Excellent

Purity: 99.79%

Catalog No. T9470Cas No. 2320462-65-3

HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$77	In Stock	In Stock
5 mg	$176	In Stock	In Stock
10 mg	$290	In Stock	In Stock
25 mg	$473	In Stock	In Stock
50 mg	$648	In Stock	In Stock
100 mg	$893	In Stock	In Stock
200 mg	$1,180	-	In Stock
1 mL x 10 mM (in DMSO)	$176	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).
Targets&IC50	MST2:78.5 nM (IC50), FLT3:25.4 nM (IC50), HPK1:2.6 nM (IC50), AMPK α1:44.3 nM (IC50), MST1:55.1 nM (IC50), c-Kit:45.7 nM (IC50), GLK/MAP4K3:140 nM (IC50), ICK:65.1 nM (IC50), FMS:3.2 nM (IC50), IRAK4:59 nM (IC50)

Chemical Properties

Molecular Weight	458.47
Formula	C₂₄H₂₂N₆O₄
Cas No.	2320462-65-3
Smiles	CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12
Relative Density.	1.404 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (272.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1812 mL	10.9058 mL	21.8117 mL	109.0584 mL
5 mM	0.4362 mL	2.1812 mL	4.3623 mL	21.8117 mL
10 mM	0.2181 mL	1.0906 mL	2.1812 mL	10.9058 mL
20 mM	0.1091 mL	0.5453 mL	1.0906 mL	5.4529 mL
50 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1812 mL
100 mM	0.0218 mL	0.1091 mL	0.2181 mL	1.0906 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc