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Oseltamivir phosphate

Name: Oseltamivir phosphate
Brand: TargetMol
SKU: T1486
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1486Cas No. 204255-11-8

Alias GS 4104

Oseltamivir phosphate (GS 4104) is a neuraminidase (NA) inhibitor with oral activity. Oseltamivir phosphate has antiviral activity and is effective against a wide range of influenza viruses, inhibiting mature influenza viruses from breaking away from host cells.

Oseltamivir phosphate

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Purity: 99.94%

Catalog No. T1486Alias GS 4104Cas No. 204255-11-8

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$36	In Stock	In Stock
100 mg	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Oseltamivir phosphate (GS 4104) is a neuraminidase (NA) inhibitor with oral activity. Oseltamivir phosphate has antiviral activity and is effective against a wide range of influenza viruses, inhibiting mature influenza viruses from breaking away from host cells.
Targets&IC50	MDCK cells:1.1 μM, A/H3N2 virus:0.42 ± 0.29 µM (EC50)
In vitro	METHODS: Preparation of D-Luciferin potassium for in vitro bioluminescence analysis: 1. Prepare 200× D-Luciferin reserve solution (30 mg/mL) with sterile water and mix gently until all dissolved. It can be used immediately after preparation or stored at -20℃. 2. Prepare 1× D-Luciferin (150 µg/mL) working solution in preheated tissue culture medium. 3. Aspirate the medium from the cultured cells. 4. Add 1× D-Luciferin solution to the cells before imaging. Incubate the cells at 37°C for a short period of time before imaging to increase signal.
In vivo	For in vivo experiments at higher doses, D-Luciferin potassium (T4139) or D-Luciferin Sodium (T19743) are recommended.
Cell Research	Cells are incubated in 96-well plates (5,000 cells/well) and allowed to adhere for 24 hours in 1× DMEM media containing 10% FCS. The media are replaced with fresh DMEM media containing 5% FCS with or without various concentrations of tamoxifen or OP for indicated time periods. Cell viability is tested using WST-1 cell proliferation assay.(Only for Reference)
Synonyms	GS 4104

Chemical Properties

Molecular Weight	410.4
Formula	C₁₆H₂₈N₂O₄·H₃PO₄
Cas No.	204255-11-8
Smiles	[C@H]1([C@H]([C@@H](C=C(C1)C(=O)OCC)OC(CC)CC)NC(=O)C)N.P(=O)(O)(O)O
Relative Density.	1.08g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242.5 mg/mL (590.89 mM), Sonication is recommended.

H2O: 80 mg/mL (194.93 mM), Sonification is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4366 mL	12.1832 mL	24.3665 mL	121.8324 mL
5 mM	0.4873 mL	2.4366 mL	4.8733 mL	24.3665 mL
10 mM	0.2437 mL	1.2183 mL	2.4366 mL	12.1832 mL
20 mM	0.1218 mL	0.6092 mL	1.2183 mL	6.0916 mL
50 mM	0.0487 mL	0.2437 mL	0.4873 mL	2.4366 mL
100 mM	0.0244 mL	0.1218 mL	0.2437 mL	1.2183 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc