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CP 154526 hydrochloride

🥰Excellent
Catalog No. T22682Cas No. 257639-98-8
Alias CP-154526 hydrochloride, CP154526 hydrochloride

CP 154526 hydrochloride is a blood-brain barrier-penetrant, selective CRF1 (corticotropin-releasing factor receptor 1) antagonist (Ki = 2.7 nM) exhibiting thousands of times greater selectivity for CRF1 over CRF2, with anxiolytic and antidepressant activities.

CP 154526 hydrochloride

CP 154526 hydrochloride

🥰Excellent
Purity: 99.94%
Catalog No. T22682Alias CP-154526 hydrochloride, CP154526 hydrochlorideCas No. 257639-98-8
CP 154526 hydrochloride is a blood-brain barrier-penetrant, selective CRF1 (corticotropin-releasing factor receptor 1) antagonist (Ki = 2.7 nM) exhibiting thousands of times greater selectivity for CRF1 over CRF2, with anxiolytic and antidepressant activities.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$45-In Stock
5 mg$106-In Stock
10 mg$172-In Stock
25 mg$378-In Stock
50 mg$629-In Stock
100 mg$886-In Stock
1 mL x 10 mM (in DMSO)$117-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
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Product Introduction

Bioactivity
Description
CP 154526 hydrochloride is a blood-brain barrier-penetrant, selective CRF1 (corticotropin-releasing factor receptor 1) antagonist (Ki = 2.7 nM) exhibiting thousands of times greater selectivity for CRF1 over CRF2, with anxiolytic and antidepressant activities.
Targets&IC50
CRF1:2.7 nM (Ki)
In vivo
CP 154526 hydrochloride (1-10 mg/kg, single intraperitoneal injection) demonstrated anxiolytic activity characteristics in the elevated plus maze behavioral test in rats [2].
SynonymsCP-154526 hydrochloride, CP154526 hydrochloride
Chemical Properties
Molecular Weight400.99
FormulaC23H33ClN4
Cas No.257639-98-8
SmilesCl.N=1C(=NC(=C2C1N(C=C2C)C=3C(=CC(=CC3C)C)C)N(CC)CCCC)C
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (199.51 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4938 mL12.4691 mL24.9383 mL124.6914 mL
5 mM0.4988 mL2.4938 mL4.9877 mL24.9383 mL
10 mM0.2494 mL1.2469 mL2.4938 mL12.4691 mL
20 mM0.1247 mL0.6235 mL1.2469 mL6.2346 mL
50 mM0.0499 mL0.2494 mL0.4988 mL2.4938 mL
100 mM0.0249 mL0.1247 mL0.2494 mL1.2469 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

CP-154526CP154526CP 154526
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