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TMPyP4 tosylate

Name: TMPyP4 tosylate
Brand: TargetMol
SKU: T13174
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13174Cas No. 36951-72-1

Alias TMP 1363

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and telomerase inhibitor that exhibits antitumor effects in osteosarcoma cell lines.

TMPyP4 tosylate

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Purity: 99.85%

Catalog No. T13174Alias TMP 1363Cas No. 36951-72-1

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and telomerase inhibitor that exhibits antitumor effects in osteosarcoma cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	In Stock
50 mg	$60	-	In Stock
100 mg	$97	-	In Stock
200 mg	$148	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:Purple

Resource Download

COA HNMR HPLC

Product Introduction

TMPyP4 tosylate AI Summary

TMPyP4 tosylate is a multi-faceted bioactive compound with significant inhibitory effects across various biological activities and targets. It inhibits PrP-res formation in mouse ScN2a cells and prion Fukuoka1 strain infected mouse N2a#58 cells with IC50 values of 130.0 nM and 160.0 nM, respectively. The compound also demonstrates potent telomerase inhibition across multiple assays against Thermus aquaticus DNA polymerase, tetrahymena telomerase, and human HeLa cells, with IC50 values ranging from 60.0 nM to 150.0 nM, and achieves maximum inhibition in some cases. TMPyP4 tosylate binds to HIV 1 HXB2 G-quadruplex LTR DNA sequences, stabilizing these structures as indicated by increases in melting temperature (Delta Tm) in the presence of K+. It also exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus and Burkholderia cepacia, particularly under specific irradiation conditions. The compound binds and inhibits human ACC1 promoter G-quadruplex DNA, showing significant binding affinities and inhibition of ACC1 gene expression in human HeLa cells. It also demonstrates antiproliferative activity against various cancer cell lines including MDA-MB-231, PC3, OVCAR3, bone marrow cells, and MCR5A, with GI50 values ranging around 14,000 to 16,800 nM, and telomerase inhibition in MDA-MB-231 cells ranging from 60.0% to 80.0%. TMPyP4 tosylate has antileishmanial activity against Leishmania major promastigotes (IC50 = 20820.0 nM), but displays lesser potency against Trypanosoma brucei brucei and Plasmodium falciparum, and shows cytotoxicity against human MRC5 cells at high concentrations. It strongly binds and stabilizes various G-quadruplex DNA structures and demonstrates photodynamic antibacterial activity against Pseudomonas aeruginosa, as well as photodynamic cytotoxicity against human A549 cells with significant light-mediated cell growth inhibition (IC50 = 300.0 nM). This extensive profile positions TMPyP4 tosylate as a valuable agent for potential therapeutic applications in prion diseases, telomerase-related conditions, bacterial infections, cancer, and diseases associated with G-quadruplex DNA targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and telomerase inhibitor that exhibits antitumor effects in osteosarcoma cell lines.
Synonyms	TMP 1363

Chemical Properties

Molecular Weight	1363.6
Formula	C₇₂H₆₆N₈O₁₂S₄
Cas No.	36951-72-1
Smiles	Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.CN1CC=C(C=C1)c1c2ccc(n2)c(C2=CCN(C)C=C2)c2ccc([nH]2)c(C2=CCN(C)C=C2)c2ccc(n2)c(C2=CCN(C)C=C2)c2ccc1[nH]2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 6.2 mg/mL (4.55 mM), Sonication is recommended.

DMSO: 18.33 mg/mL (13.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (0.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7334 mL	3.6668 mL	7.3335 mL	36.6676 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.1467 mL	0.7334 mL	1.4667 mL	7.3335 mL
10 mM	0.0733 mL	0.3667 mL	0.7334 mL	3.6668 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc